Archives: FAQs

Some prodrugs may be detected in plasma along with their active moiety while others may not. Therefore, to search data involving prodrugs you need perform the search using both the prodrug and the active moiety as objects and precipitants. 

Yes, in vitro metabolism data can be searched based on a specific in vitro experimental system using the following query: Queries > Additional Queries > Other Queries. In the first subquery “System”, type or select the specific system of interest.

If you are interested in clinical data, you type the compound name in your query starting by “endogenous”, then you will have the whole list of biomarkers included in DIDB. If you wish to retrieve in vitro data, you can perform the query using the compound name directly without typing “endogenous”.

To retrieve all data involving cannabinoids use the following queries: Basic Queries > Therapeutic Class Queries > One Therapeutic Class, and type in “Cannabinoids”, select between object or precipitant and “in vitro” and/or “in vivo”.

Natural products (NP) have often multiple ingredients. When a NP is considered as precipitant in vivo, its ingredients are only found when they have been administered as such. For example, most of the grapefruit juice studies will be found under precipitant = grapefruit Juice, while its main ingredient bergamottin will only appear as a precipitant when specifically formulated and administered as bergamottin only. So, the best way to retrieve all results related to grapefruit juice is to include grapefruit, grapefruit juice, and bergamottin together in the search. On the other hand, to view in vivo data related to a NP as object, users need to query using the names of its ingredients since they are the entities measured in the studies (and not the parent NP).