Yes. You can include the results in pdf exported from the DIDB DDI Calculator and reference it as “The Certara DIDB DDI Calculator (https://www.druginteractionsolutions.org/) was used.”
Archives: FAQs
How do I create my account to access DIDB?
Firstly, your organization should hold a DIDB license for its employees to register to access the database, and you need to get your organization’s DIDB credentials.
To register, follow the link: https://www.druginteractionsolutions.org/register/. Enter your organization’s DIDB credentials and then provide your name and a work email address to create your own user account.
It is worth emphasizing that a user account is personal and cannot be shared with anyone within your company nor outside. Anyone within your organization interested in accessing the DIDB (even infrequently) should create their own user account.
Does DIDB contain information from post-marketing requirements and post-marketing commitments (PMRs and PMCs)?
As of November 2023, DIDB contains PMRs and PMCs for drugs approved by the FDA in 2014, 2015, and 2016. The DDI, hepatic impairment, and renal impairment results can be found under the drug’s original NDA or BLA numbers. Updated label recommendations are also presented in the drug DDI Summary.
Having access to this additional information is key to fully understand the DDI profile of NMEs, and the DIDB Editorial Team is now working on PMR/PMC data for drugs approved in 2017 and 2018.
How do I cite DIDB in publications?
To reference DIDB in publications, you may write:
“Copyright Certara Drug Interaction Database (DIDB), accessed on: … [Fill in with date of extraction of the data/information]”.
Does DIDB contain PK and compound parameters?
Yes, DIDB contains 25 PK and compound parameters to support PBPK modeling and simulations.
Here is the list: absolute bioavailability, accumulation ratio, B/P, Cmax (mass/volume), Cmax (molar), Cmax dose/duration, clearance, clinically recommended dosage, dose proportionality, elimination pathway, Fa, Fe, Fg, Fm in vitro, Fm in vivo, Fu in vitro, Ka, LogP, permeability, pKa, plasma protein binding, solubility (at different pH), T1/2, Tmax, Vd.
Does DIDB contain gastric pH-dependent drug interaction data?
Yes, DIDB contains clinical drug interaction data with acid-reducing agents such as antacids, histamine H2-receptor antagonists, and proton pump inhibitors (PPIs). This type of data can be easily identified based on its unique drug interaction meachanism categorized in DIDB.
How can I retrieve all data related to QT interval prolongation potential of drugs?
A quick way to find all the relevant data regarding QT interval prolongation (from both the literature and recent NDA/BLA reviews) is to use the following query:
Additional Queries > QT interval Queries > QT summaries in a searchable table
Other QT interval queries include:
– A list of all drugs with clinical evidence of QT interval prolongation potential,
– In vivo studies reporting Torsades de Pointes/Ventricular Fibrillation as a side effect,
– In vivo studies reporting QT Interval Prolongation as a side effect, and
– In vivo drug interaction studies in which QT interval measurements were performed.
Can I find fu,mic or fu,hep values in DIDB?
Yes. These parameters are presented in the compound PK profile under the name of “Fu in vitro“. The specific in vitro system used to obtain the fu value is presented after the value, when available. You can use the following query to find such values of a specific compound: Monographs (located at the top panel of DIDB homepage) > PK profiles (link). The Fu in vitro values presented in the PK profile is usually available for newly marketed drugs obtained from the NDA reviews. Additionally, fu in vitro values are curated together with specific in vitro metabolism data if they are provided within the same citation. Thus, you may find the fu in vitro values of the drug of interest using an in vitro metabolism query, e.g., Km/Vmax/CLint. In the result, such values are presented in the column of “Fu in vitro“, when available.
How can I exclude simulation data (PBPK and population PK) from the query results?
You can use the “Advanced Table Search” function associated with the result table to easily exclude simulation data, if there is such data in the result. First, you need to check if simulation data exists in your result. On the table result page, you can either type “PBPK” or “population PK” in the first filter row or review all the options in the second filter row in the column of “Study Design”. If such data exists, then click “Advanced Table Search” above the table and “Add Condition” will show. Click “Add Condition”, and select “Study design” Column, “Not” Condition, and any option containing “PBPK Modeling” Value. Of note, there may be multiple options containing “PBPK Modeling”, thus you need to click “Add Condition” to exclude all the other study design options including “PBPK Modeling” one by one. Similarly, you can remove population PK data by selecting “Population PK Analysis”.
Can I find fm values in DIDB?
Yes. Fm in vitro and Fm in vivo are parameters presented in the compound PK profile. You can use the following query to find fm values of a specific compound if they are available: Monographs (located at the top panel of DIDB homepage) > PK profiles (link).