Acid-reducing agents in DIDB are categorized into three therapeutic classes: Antacids, H-2 Receptor Antagonists, and Proton Pump Inhibitors. To find all drug interaction studies involving acid-reducing agents, navigate to Basic Queries > Therapeutic Class Queries > One Therapeutic Class. Specify the role of acid-reducing agents as either Objects or Precipitants, then select “Antacids”, “H-2 Receptor Antagonists”, or “Proton Pump Inhibitors” in the Therapeutic Class field and choose the desired study condition “in vitro” and/or “in vivo”.
To find studies with percent changes in AUC or CL, go to Advanced queries > AUC-CL Change Queries > with Therapeutic Class. If your focus is solely on absorption-based drug interaction data, select “other mechanism” as the option. All absorption-based DDI studies in DIDB are categorized under other mechanisms and are annotated with specific mechanisms such as binding/chelation, gastrointestinal motility, or pH dependency.