For in vitro data, use the “Enzyme Queries” and “Transporter Queries” to find variants of a polymorphic enzyme or transporter. Enter “variant” in the designated enzyme or transporter field, then select the specific enzyme or transporter. The studied variant is usually listed along with the kinetic parameters (e.g., Km, Vmax, CLint, IC50) or in the comments of each entry.
For clinical data, the “Pharmacogenetics Queries” retrieve information on how polymorphic genes of enzymes and transporters affect drug disposition. The “Search for Citations” query generates a list of citations for a specific compound, gene, or population characteristic. Each citation includes links to pharmacogenetic websites for background information, allowing users to explore specific variants of the polymorphic gene under investigation.
In the “Search for Quantitative Results” query, the selected compound or gene includes hyperlinks at the top of the result page, directing users to dedicated pharmacogenetic or compound websites for further exploration. The result table displays the percent change in various PK parameters based on the genotype investigated and compared to the reference (normal) genotype. Results for specific genotype variants can be refined using the table’s filtering features.
Additionally, for clinical DDI studies performed in populations with different phenotypes or genotypes, the variant information is described in the population field of each entry.