The DDI Marker Studies Knowledgebase (replacing the previous combined and individual lists of CYP/P-gp substrates and perpetrators) has been updated in October 2022, and is available in the DIDB Resource Center.
We continue to expand the Knowledgebase by adding more transporter data. In this update, 42 compounds (including 13 endogenous biomarkers) were added as OATP1B/1B3 substrates based on clinical DDI data and/or pharmacogenetic findings. In addition, 16 compounds were identified as substates/inhibitors/inducers of CYP enzymes and transporters (P-gp and BCRP). Among them, 20% could lead to strong drug interactions.
In addition to substrates, inhibitors and inducers of CYPs and transporters, the Knowledgebase provides useful information on the compounds therapeutic class, clinical recommended dosage, pharmacokinetics (e.g. dose proportionality accumulation ratio, time to steady-state), QT prolongation, and NTI characteristics.
As always, feel free to contact us if you have any questions or comments.